Studies have shown that a slight drop in blood-sugar levels can inhibit self-control, since the frontal lobes require lots of energy in order to function. Look, for example, at this experiment led by Roy Baumeister, a psychologist at Florida State University. The experiment began with a large group of undergraduates performing a mentally taxing activity that involved watching a video while ignoring the text of random words scrolling on the bottom of the screen. (It takes a conscious effort to not pay attention). The students were then offered some lemonade. Half of them got lemonade made with real sugar, and the other half got lemonade made with a sugar substitute.
After giving the glucose time to enter the bloodstream and perfuse the brain (about fifteen minutes), Baumeister had the students make decisions about apartments. It turned out that the students who were given the drink without real sugar were significantly more likely to rely on instinct and intuition when choosing a place to live, even if that led them to choose the wrong places. The reason, according to Baumeister, is that the rational brains of these students were simply to exhausted to think. They'd needed a restorative sugar fix, and all they'd gotten was Splenda.
This research can also help explain why we get cranky when we're hungry and tired: the brain is less able to suppress the negative emotions sparked by small annoyances. A bad mood is really just a rundown prefrontal cortex.
Jonah Lehrer
How We Decide